Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 19 October 2004
Vol. 2004, Issue 255, p. tw377
[DOI: 10.1126/stke.2552004tw377]


BIOCHEMISTRY Tissue Plasminogen--and PDGF--Activator

Tissue plasminogen activator has been well characterized as a serine protease that functions in control of blood clotting by releasing the protease plasmin from the inactive zymogen plasminogen. Now evidence is accumulating that indicates that tPA may actually have broader roles. Fredriksson et al. searched for the protease responsible for activation of platelet-derived growth factor C (PDGF-C). Cleavage of an N-terminal CUB (complement-binding) domain is required to activate PDGF-CC dimers and allow PDGFC to stimulate the PDGF receptor α. Such activation of PDGF-CC was promoted by media from cells expressing tPA. Cells from knockout animals lacking tPA failed to activate PDGF-CC and showed inhibited growth. This study and others that implicate roles for tPA in modifying the NMDA receptor and activating brain-derived neurotophic factor suggest that clotting is not the only process regulated by tPa.

L. Fredriksson, H. Li, C. Fieber, X. Li, U. Eriksson, Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23, 3793-3802 (2004). [Abstract] [Full Text]

Citation: Tissue Plasminogen--and PDGF--Activator. Sci. STKE 2004, tw377 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882