Focus Issue—The Dynamics of Gene Expression

Nancy R. Gough^*

Managing Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: It is gene expression that defines a cell's identity. Science, Science's Science of Aging Knowledge Environment (SAGE KE), and Science's STKE focus attention on the highly dynamic nature of gene expression. Mechanisms governing selective gene expression in multigene families, as well as those by which cis- and trans-acting factors contribute to regulation of gene expression, are topics under discussion. In addition, new methodologies allow researchers to gain insight into gene expression at the level of single cells and provide a glimpse at the real-time interactions among proteins and DNA.

*Contact information. E-mail, ngough{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Transcription
Chromatin-Associated PKC

Nancy R. Gough (22 March 2011)
Sci. Signal. 4 (165), ec85. [DOI: 10.1126/scisignal.4165ec85]
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EDITORIAL GUIDES
Posttranscriptional Regulation
Focus Issue: Signals for Gene Expression

Wei Wong (2 November 2010)
Sci. Signal. 3 (146), eg10. [DOI: 10.1126/scisignal.3146eg10]
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RESEARCH ARTICLES
Transcription
Complexity in Transcription Control at the Activation Domain–Mediator Interface

Michael A. Balamotis, Mario A. Pennella, Jennitte L. Stevens, Bohdan Wasylyk, Andrew S. Belmont, and Arnold J. Berk (5 May 2009)
Sci. Signal. 2 (69), ra20. [DOI: 10.1126/scisignal.1164302]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

In Science Magazine

INTRODUCTION TO SPECIAL ISSUE
Solving Gene Expression

Barbara R. Jasny and Leslie Roberts (22 October 2004)
Science 306 (5696), 629. [DOI: 10.1126/science.306.5696.629]
 |  Summary »  |  PDF »