Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 26 October 2004
Vol. 2004, Issue 256, p. re17
[DOI: 10.1126/stke.2562004re17]


Selective Gene Expression in Multigene Families from Yeast to Mammals

Jacob Z. Dalgaard* and Sonya Vengrova

Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, UK.

Abstract: Exclusive gene expression, where only one member of a gene or gene cassette family is selected for expression, plays an important role in the establishment of cell identity in several biological systems. Here, we compare four such systems: mating-type switching in fission and budding yeast, where cells choose between expressing one of the two different mating-type cassettes, and immunoglobulin and odorant receptor gene expression in mammals, where the number of gene choices is substantially higher. The underlying mechanisms that establish this selective expression pattern in each system differ in almost every detail. In all four systems, once a successful gene activation event has taken place, a feedback mechanism affects the fate of the cell. In the mammalian systems, feedback is mediated by the expressed cell surface receptor to ensure monoallelic gene expression, whereas in the yeasts, the expressed gene cassette at the mating-type locus affects donor choice during the subsequent switching event.

*Corresponding author. E-mail: j.dalgaard{at}

Citation: J. Z. Dalgaard, S. Vengrova, Selective Gene Expression in Multigene Families from Yeast to Mammals. Sci. STKE 2004, re17 (2004).

Read the Full Text

Schizosaccharomyces pombe Switches Mating Type by the Synthesis-Dependent Strand-Annealing Mechanism.
T. Yamada-Inagawa, A. J. S. Klar, and J. Z. Dalgaard (2007)
Genetics 177, 255-265
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882