Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 26 October 2004
Vol. 2004, Issue 256, p. tw386
[DOI: 10.1126/stke.2562004tw386]


CALCIUM SIGNALING Regulator of Calcium Signaling

Many calcium-dependent signals are mediated by the calcium sensor protein calmodulin. Rakhilin et al. describe a calmodulin-binding protein that appears to function at the interface of two major signaling pathways activated by G protein-coupled receptors--one mediated by the cyclic adenosine monophosphate-dependent protein kinase (PKA) and the other by phospholipase C and intracellular calcium signals. Alterations in signaling by such receptors are associated with a number of major diseases of the nervous system. This protein, called RCS for regulator of calcium signaling, bound to and inhibited calmodulin. RCS binding to calmodulin was enhanced when RCS was phosphorylated by PKA. Phosphorylated RCS inhibited activity of the calcium/calmodulin-dependent protein phosphatase (PP2B). Phosphorylated RCS is thus poised both to enhance signaling through PKA (because substrates of PKA are often dephosphorylated by PP2B) and, at the same time, to inhibit the action of calmodulin, promoting a range of calcium-dependent signals.

S. V. Rakhilin, P. A. Olson, A. Nishi, N. N. Starkova, A. A. Fienberg, A. C. Nairn, D. J. Surmeier, P. Greengard, A network of control mediated by regulator of calcium/calmodulin-dependent signaling. Science 306, 698-701 (2004). [Abstract] [Full Text]

Citation: Regulator of Calcium Signaling. Sci. STKE 2004, tw386 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882