The Moving Frontier in Nitric Oxide–Dependent Signaling

Carl Nathan^*

Department of Microbiology and Immunology, Weill Cornell Medical College, and Programs in Immunology and Microbial Pathogenesis and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA.

Abstract: New discoveries are expanding our view of the role of nitric oxide (NO) in mammalian physiology by revealing new types, amounts, and fates of molecules modified in vivo by NO and its derivatives, as well as the profound augmentation of some of NO’s actions at physiologic levels of O₂. Investigators have identified a new form of endogenous reversible N-nitrosation reactions in vivo, that of proteins; a new class of endogenously nitrated bioactive molecules in vivo, nitro-fatty acids; and the ability of NO-dependent posttranslational modifications to control the half-life and destination of key regulatory proteins.

*Contact information. Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA. E-mail: cnathan{at}med.cornell.edu

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Nitric Oxide
Two Ways to Breathe Easier Without iNOS

Elizabeth M. Adler (18 October 2011)
Sci. Signal. 4 (195), ec288. [DOI: 10.1126/scisignal.4195ec288]
 |  Abstract »

EDITORIAL GUIDES
Cell Biology
Focus Issue: The Long and Short of Redox Signaling

Nancy R. Gough (29 September 2009)
Sci. Signal. 2 (90), eg12. [DOI: 10.1126/scisignal.290eg12]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Inflammation
NO Link Between Notch and Inflammation?

Annalisa M. VanHook (29 April 2008)
Sci. Signal. 1 (17), ec154. [DOI: 10.1126/stke.117ec154]
 |  Abstract »

EDITORS' CHOICE
NEUROTOXICITY
Oh, NO! The Ironic Route to Neurotoxicity

(22 August 2006)
Sci. STKE 2006 (349), tw289. [DOI: 10.1126/stke.3492006tw289]
 |  Abstract »

PERSPECTIVES
STKE Perspectives
OxyR: A Molecular Code for Redox Sensing?

John D. Helmann (5 November 2002)
Sci. STKE 2002 (157), pe46. [DOI: 10.1126/scisignal.1572002pe46]
 |  Abstract »  |  Full Text »  |  PDF »

PROTOCOLS
STKE Biochemical Methods and Assays
The Biotin Switch Method for the Detection of S-Nitrosylated Proteins

Samie R. Jaffrey and Solomon H. Snyder (12 June 2001)
Sci. STKE 2001 (86), pl1. [DOI: 10.1126/scisignal.862001pl1]
 |  Abstract »  |  Full Text »  |  PDF »

REVIEWS
STKE Reviews
S-Nitrosylation Is Emerging as a Specific and Fundamental Posttranslational Protein Modification: Head-to-Head Comparison with O-Phosphorylation

Paul Lane, Gang Hao, and Steven S. Gross (12 June 2001)
Sci. STKE 2001 (86), re1. [DOI: 10.1126/scisignal.862001re1]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: