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Sci. STKE, 9 November 2004
Vol. 2004, Issue 258, p. tw409
[DOI: 10.1126/stke.2582004tw409]

SECRETION Candid Camera on Secretion

The interaction of SNARE proteins, like SNAP25, syntaxin, or synaptobrevin, is a key event in the fusion intracellular membranes, such as when secretory vesicles fuse with the plasma membrane during regulated secretion. An et al. engineered a series of fluorescent SNAP25 analogs that change color when SNAREs interact in living cells. In time-resolved recordings, SNARE complexes could be observed to assemble and disassemble when single cells were stimulated to secrete.

S. J. An, W. Almers, Tracking SNARE complex formation in live endocrine cells. Science 306, 1042-1046 (2004). [Abstract] [Full Text]

Citation: Candid Camera on Secretion. Sci. STKE 2004, tw409 (2004).

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