Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 16 November 2004
Vol. 2004, Issue 259, p. tw416
[DOI: 10.1126/stke.2592004tw416]


DRUG DISCOVERY Illuminating Drug Discovery

In drug discovery, profiling technologies are important for measuring drug actions both on the desired target and on other targets. High-throughput methods such as transcriptional and proteomic profiling provide data on the responses of populations of cells, normally at single-drug concentrations. Perlman et al. describe a method for high-throughput cytological profiling that combines automated microscopy, image analysis, and statistical analysis. Using multiple fluorescent probes that cover a range of cell biological functions, they profiled the dose-dependent effects of 100 drugs on cultured mammalian cells. They succeeded in categorizing drugs of known mechanism and suggested targets for drugs of uncertain mechanism.

Z. E. Perlman, M. D. Slack, Y. Feng, T. J. Mitchison, L. F. Wu, S. J. Altschuler, Multidimensional drug profiling by automated microscopy. Science 306, 1194-1198 (2004). [Abstract] [Full Text]

Citation: Illuminating Drug Discovery. Sci. STKE 2004, tw416 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882