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Sci. STKE, 23 November 2004
Vol. 2004, Issue 260, p. tr10
[DOI: 10.1126/stke.2602004tr10]


The Jak-STAT Pathway Stimulated by Interferon α or Interferon β

Curt M. Horvath

Department of Medicine, Evanston Northwestern Healthcare Research Institute, and Departments of Medicine and Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208 USA.

Abstract: Type I interferons, such as interferon α and interferon β (IFN-α and β), signal through a Janus kinase (Jak) to signal transduction and activator of transcription (STAT) pathway to stimulate gene expression. In response to ligand binding, the receptors dimerize, Jaks phosphorylate STAT1 and STAT2, which then dimerize and interact with a third transcriptional regulator IFN regulatory factor 9 (IRF9) to stimulate gene expression. IFN-α is the main innate antiviral cytokine and is essential for effective immune response to viral infection. The animation shows activation of STAT-responsive gene expression in response to type I IFNs.

*Corresponding author. E-mail, curt.horvath{at}

Citation: C. M. Horvath, The Jak-STAT Pathway Stimulated by Interferon α or Interferon β. Sci. STKE 2004, tr10 (2004).

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