The Jak-STAT Pathway Stimulated by Interleukin 6

Curt M. Horvath

Department of Medicine, Evanston Northwestern Healthcare Research Institute, and Departments of Medicine and Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, 60208 USA.

Abstract: Signal transducer and activator of transcription 3 (STAT3) is widely expressed and activated by a variety of growth-regulating signals as well as diverse cytokines that use gp130 signaling receptors. STAT3 is critical for embryonic development and stem cell biology, as well as inflammation, growth regulation, and multiple immune regulatory and homeostatic functions. The animation shows activation of STAT3 in response to interleukin 6 (IL6), a cytokine involved in triggering inflammation.

*Corresponding author. E-mail, curt.horvath{at}mssm.edu

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
GI INFLAMMATION
Acetylcholine as Cytokine

(2 August 2005)
Sci. STKE 2005 (295), tw280. [DOI: 10.1126/stke.2952005tw280]
 |  Abstract »

TEACHING RESOURCES
STKE Teaching Resources
The Jak-STAT Pathway Stimulated by Interferon α or Interferon β

Curt M. Horvath (23 November 2004)
Sci. STKE 2004 (260), tr10. [DOI: 10.1126/stke.2602004tr10]
 |  Abstract »  |  Resource Details »

TEACHING RESOURCES
STKE Teaching Resources
The Jak-STAT Pathway Stimulated by Interferon

Curt M. Horvath (23 November 2004)
Sci. STKE 2004 (260), tr8. [DOI: 10.1126/stke.2602004tr8]
 |  Abstract »  |  Resource Details »

REVIEWS
STKE Reviews
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes

Robert M. Stroud and James A. Wells (4 May 2004)
Sci. STKE 2004 (231), re7. [DOI: 10.1126/stke.2312004re7]
 |  Gloss »  |  Abstract »  |  Full Text »  |  PDF »

PERSPECTIVES
STKE Perspectives
The Cytokine Receptor gp130: Faithfully Promiscuous

Gerhard Müller-Newen (23 September 2003)
Sci. STKE 2003 (201), pe40. [DOI: 10.1126/scisignal.2012003pe40]
 |  Abstract »  |  Full Text »  |  PDF »

DATABASE OF CELL SIGNALING
STAT3 Pathway

David Aaronson and Curt M. Horvath
Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_9229
 |  Overview »  |  Canonical Pathway »  |  Animation »

In Science Magazine

VIEWPOINT
A Road Map for Those Who Don't Know JAK-STAT

David S. Aaronson and Curt M. Horvath (31 May 2002)
Science 296 (5573), 1653. [DOI: 10.1126/science.1071545]
 |  Abstract »  |  Full Text »  |  PDF »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: