Sci. STKE, 21 December 2004
BIOCHEMISTRY Back Door to Phosphorylation
Protein phosphorylation typically occurs through the catalytic activity of a kinase that transfers the phosphate moiety from adenosine triphosphate to a substrate. Saiardi et al. (see the Perspective by York and Hunter) show that the inositol pyrophosphate IP7 can act as a phosphate donor to eukaryotic proteins. The nonenzymatic covalent protein modification was observed in cell extracts and in yeast cells. Because IP7 and many of its targets have been implicated in various biological processes, this type of phosphorylation may represent an intracellular signaling mechanism.
Citation: Back Door to Phosphorylation. Sci. STKE 2004, tw455 (2004).
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