Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 21 December 2004
Vol. 2004, Issue 264, p. tw457
[DOI: 10.1126/stke.2642004tw457]

EDITORS' CHOICE

AGING Linking Age Control Mechanisms

Four different factors have been linked independently to mammalian aging--nutrient availability, the Forkhead transcription factor Foxo3a, the nicotinamide adenine dinucleotide-dependent deacetylase SIRT1, and the tumor suppressor protein p53. Nemoto et al. now report that these elements intersect in a manner that may modulate mammalian life-span. Under conditions of nutritional stress, Foxo3a stimulates SIRT1 expression in mammalian cells, which requires p53 and two p53-binding sites within the SIRT1 promoter. Moreover, Foxo3a and p53 interaction increases under nutrient-starved conditions. The signaling pathway may constitute a homeostatic regulatory network that responds to nutrient availability and, consequently, controls aging.

S. Nemoto, M. M. Fergusson, T. Finkel, Nutrient availability regulates SIRT1 through a Forkhead-dependent pathway. Science 306, 2105-2108 (2004). [Abstract] [Full Text]

Citation: Linking Age Control Mechanisms. Sci. STKE 2004, tw457 (2004).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882