Sci. STKE, 4 January 2005
NETWORK ANALYSIS The Proteins Came in Three by Three
Maps of protein interaction networks provide a kind of blueprint of cellular functions. Comparing the presence or absence of a pair of proteins in various species can provide clues to functional associations in such networks. Bowers et al. take such logic a step further and examine the presence of groups of three proteins in 67 sequenced genomes. A search for logical relations between the three (for example, A is present only if B and C are also present) revealed 750,000 new relations between protein family members. These and higher order logical relations may be useful in modeling, engineering, and understanding biological systems.
Citation: The Proteins Came in Three by Three. Sci. STKE 2005, tw11 (2005).
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