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Sci. STKE, 4 January 2005
Vol. 2005, Issue 265, p. tw2
[DOI: 10.1126/stke.2652005tw2]

EDITORS' CHOICE

DEVELOPMENT Role of Transcription Factors in Neural Development

Neural development is often thought to be a matter of axons finding the right connections. Gray et al. highlight the importance of transcription in regulating neural development. Analysis of the mouse genome revealed more than 1000 genes that encode transcription factors. In situ hybridization studies further revealed that more than 300 transcription factors were differentially expressed in the central nervous system during development.

P. A. Gray, H. Fu, P. Luo, Q. Zhao, J. Yu, A. Ferrari, T. Tenzen, D.-I. Yuk, E. F. Tsung, Z. Cai, J. A. Alberta, L.-p. Cheng, Y. Liu, J. M. Stenman, M. T. Valerius, N. Billings, H. A. Kim, M. E. Greenberg, A. P. McMahon, D. H. Rowitch, C. D. Stiles, Q. Ma, Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306, 2255-2257 (2004). [Abstract] [Full Text]

Citation: Role of Transcription Factors in Neural Development. Sci. STKE 2005, tw2 (2005).


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