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Sci. STKE, 11 January 2005
Vol. 2005, Issue 266, p. tw22
[DOI: 10.1126/stke.2662005tw22]

EDITORS' CHOICE

IMMUNOLOGY Calcium Channels in T Lymphocytes

Calcium represents a critical signaling mediator in a number of biological systems, including in excitable cells such as neurons and in lymphocytes of the immune system. However, the identity of channels that mediate calcium entry in lymphocytes has been unclear. Badou et al. (see Perspective by Winslow and Crabtree) find that T cells express two forms of voltage-gated calcium channel (Cav) that are required for mediating activation signals critical for normal T cell functions. Cav activity was increased directly by T cell receptor stimulation.

A. Badou, S. Basavappa, R. Desai, Y.-Q. Peng, D. Matza, W. Z. Mehal, L. K. Kaczmarek, E. L. Boulpaep, R. A. Flavell, Requirement of voltage-gated calcium channel ß4 subunit for T lymphocyte functions. Science 307, 117-121 (2005). [Abstract] [Full Text]

M. M. Winslow, G. R. Crabtree, Decoding calcium signaling. Science 307, 56-57 (2005). [Summary] [Full Text]

Citation: Calcium Channels in T Lymphocytes. Sci. STKE 2005, tw22 (2005).

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