Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 18 January 2005
Vol. 2005, Issue 267, p. pe1
[DOI: 10.1126/stke.2672005pe1]


TRKing Signals Through the Golgi

Alexander Sorkin*

Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado, USA.

Abstract: The subcellular localization of transmembrane receptors and other signaling proteins has emerged as a key component in the regulation of the intensity and specificity of their activity. Recent research indicates that immature TrkA neurotrophin receptors are transactivated in the Golgi apparatus after stimulation of neuropeptide pituitary adenylate cyclase–activating polypeptide PAC1 receptors or adenosine A2A receptors. Transactivation occurs independently of the TrkA extracellular ligand, nerve growth factor (NGF), through a signaling pathway that is distinct from that used in the transactivation of other receptor tyrosine kinases and has consequences distinct from those elicited by NGF at the plasma membrane.

*Contact information: Department of Pharmacology, University of Colorado Health Sciences Center, Post Office Box 6511, Aurora, CO 80045–3649, USA. Telephone: 303-724-3649; fax: 303-724-3663; e-mail: Alexander.sorkin{at}

Citation: A. Sorkin, TRKing Signals Through the Golgi. Sci. STKE 2005, pe1 (2005).

Read the Full Text

Extracellular pH and Neuronal Depolarization Serve as Dynamic Switches to Rapidly Mobilize trkA to the Membrane of Adult Sensory Neurons.
G. E. Bray, Z. Ying, L. D. Baillie, R. Zhai, S. J. Mulligan, and V. M. K. Verge (2013)
J. Neurosci. 33, 8202-8215
   Abstract »    Full Text »    PDF »
Defective Axonal Transport of Rab7 GTPase Results in Dysregulated Trophic Signaling.
K. Zhang, R. Fishel Ben Kenan, Y. Osakada, W. Xu, R. S. Sinit, L. Chen, X. Zhao, J.-Y. Chen, B. Cui, and C. Wu (2013)
J. Neurosci. 33, 7451-7462
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882