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Sci. STKE, 18 January 2005
Vol. 2005, Issue 267, p. tr2
[DOI: 10.1126/stke.2672005tr2]


A Model for Fast-Track Exocytosis of Synaptic Vesicles

Thierry Galli1* and Volker Haucke2*

1Membrane Traffic and Neuronal Plasticity Group, INSERM U536, Institut du Fer-à-moulin, 75005 Paris, France.
2Institut für Chemie-Biochemie, Freie Universität Berlin, D-14195 Berlin, Germany.

Abstract: The animation illustrates one model for "kiss-and-run" or fast-track release of neurotransmitter through a calcium-triggered transient pore formed between the synaptic vesicle and plasma membrane. The vesicles remain attached to the plasma membrane throughout the cycle. The animation illustrates a role for SNARE proteins and dynamin in the formation and closure of the pore. The animation would be useful in both neurobiology courses, but also any cell biology course that explores calcium-regulated secretion events.

*Corresponding authors. E-mail, thierry{at} (T.G.) or vhaucke{at} (V.H.)

Citation: T. Galli, V. Haucke, A Model for Fast-Track Exocytosis of Synaptic Vesicles. Sci. STKE 2005, tr2 (2005).

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