Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 1 February 2005
Vol. 2005, Issue 269, p. tw47
[DOI: 10.1126/stke.2692005tw47]

EDITORS' CHOICE

SENSORY PERCEPTION Not So Different After All

Melanopsin is an atypical opsin protein required in vertebrates to mediate nonvisual responses to light, including regulation of circadian behavior and pupil constriction. Panda et al. report that, when expressed in Xenopus oocytes, melanopsin activates heterotrimeric G protein signaling pathways characteristic of invertebrate opsins in response to light. Melanopsin could also activate mammalian TRPC channels, whose paralogs in Drosophila serve as phototransduction channels. Thus, an invertebrate signaling system appears to be preserved in the mammalian retina.

S. Panda, S. K. Nayak, B. Campo, J. R. Walker, J. B. Hogenesch, T. Jegla, Illumination of the melanopsin signaling pathway. Science 307, 600-604 (2005). [Abstract] [Full Text]

Citation: Not So Different After All. Sci. STKE 2005, tw47 (2005).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882