|
ADVERTISEMENT 
|
Sci. STKE, 1 February 2005 EDITORS' CHOICENEUROBIOLOGY How Not to Differentiate a NeuronWhat do neuronal precursor cells and non-neuronal cells have in common? Neither expresses the genes typical of differentiated neurons. Yeo et al. now show what else is in common: expression of certain SCP phosphatases. The SCP phosphatases serve to repress the expression of neuronal genes, perhaps stabilizing non-neuronal differentiation programs or keeping progenitor cells in check as they wait for their call to action. Inhibition of the SCP phosphatase activity increased neuronal differentiation. It appears that SCP phosphatase activity acts globally to silence neuronal genes in neuronal precursors and non-neuronal cells. M. Yeo, S.-K. Lee, B. Lee, E. C. Ruiz, S. L. Pfaff, G. N. Gill, Small CTD phosphatases function in silencing neuronal gene expression. Science 307, 596-600 (2005). [Abstract] [Full Text]
Citation: How Not to Differentiate a Neuron. Sci. STKE 2005, tw48 (2005). The editors suggest the following Related Resources on Science sites:In Science Magazine
|
Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
Magazine | News | Signaling | Careers | Multimedia | Collections | Help | Site Map | RSS
Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us
© 2005 American Association for the Advancement of Science. All Rights Reserved.
AAAS is a partner of HINARI, AGORA, PatientInform, CrossRef, and COUNTER.
You have reached the bottom of the page. Back to top