Sci. STKE, 8 February 2005
CELL CYCLE A Matter of Timing?
Understanding how genes function within an organism requires an evaluation of temporal as well as physical interactions. De Lichtenberg et al. have combined confidence-scored protein-protein interaction data with microarray data to provide a detailed view of cell cycle biology in yeast. The approach was used to make predictions about gene function. Almost all cell cycle complexes contained both subunits that showed a dynamic as well as those that had an unchanging pattern of expression. The dynamic subunits were the targets of cyclin-dependent phosphorylation, and it was their expression that was associated with the time at which the complex functioned.
Citation: A Matter of Timing? Sci. STKE 2005, tw59 (2005).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882