Sci. STKE, 8 February 2005
VIROLOGY Cytokine Production and Kaposi's
When tissues are infected with Kaposi's sarcoma-associated herpesvirus (KSHV), they produce large amounts of pro-inflammatory cytokines that are linked to disease progression. McCormick and Ganem show that a viral protein, kaposin B, interacts with mitogen-activated protein kinase-associated protein kinase 2 and enhances the activity of this host-cell protein, serving to block the decay of AU-rich messenger RNAs and increase the level of secreted cytokines. This result explains the association of KSHV-related disease and enhanced cytokine production.
Citation: Cytokine Production and Kaposi's. Sci. STKE 2005, tw60 (2005).
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