Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 15 February 2005
Vol. 2005, Issue 271, p. cm1
[DOI: 10.1126/stke.2712005cm1]

CONNECTIONS MAP OVERVIEWS

Wnt/β-Catenin Pathway

Randall T. Moon*

HHMI, Department of Pharmacology, Center for Developmental Biology, University of Washington School of Medicine, Seattle, WA 98195,USA.

stkecm;CMP_5533

Abstract: Wnts are secreted glycoproteins that act as ligands to stimulate receptor-mediated signal transduction pathways in both vertebrates and invertebrates. Activation of Wnt pathways can modulate cell proliferation, survival, cell behavior, and cell fate in both embryos and adults. The Wnt/β-catenin pathway is the best understood Wnt signaling pathway, and its core components are highly conserved during evolution, although tissue-specific or species-specific modifiers of the pathway are likely. In the absence of a Wnt signal, cytoplasmic β-catenin is phosphorylated and degraded in a complex of proteins. Wnt signaling through the Frizzled serpentine receptor and low-density lipoprotein receptor-related protein-5 or -6 (LRP5 or 6) coreceptors activates the cytoplasmic phosphoprotein Dishevelled, which blocks the degradation of β-catenin. As the amount of β-catenin rises, it accumulates in the nucleus, where it interacts with specific transcription factors, leading to regulation of target genes. Inappropriate activation of the pathway in response to mutations is linked to a wide range of cancers, including colorectal cancer and melanoma. The pathway is linked to bone density syndromes and to neurodegenerative diseases, and the pathway may also be involved in the retinal disease familial exudative vitreoretinopathy.

*Contact information. Telephone, 206-543-1722; fax, 206-543-0858; e-mail, rtmoon{at}u.washington.edu

Citation: R. T. Moon, Wnt/β-Catenin Pathway. Sci. STKE 2005, cm1 (2005).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice.
A. R. Cox, C. A. Beamish, D. E. Carter, E. J. Arany, and D. J. Hill (2013)
Experimental Biology and Medicine 238, 1147-1159
   Abstract »    Full Text »    PDF »
Matrix Rigidity Activates Wnt Signaling through Down-regulation of Dickkopf-1 Protein.
M. V. Barbolina, Y. Liu, H. Gurler, M. Kim, A. A. Kajdacsy-Balla, L. Rooper, J. Shepard, M. Weiss, L. D. Shea, P. Penzes, et al. (2013)
J. Biol. Chem. 288, 141-151
   Abstract »    Full Text »    PDF »
Structural Basis of Wnt Recognition by Frizzled.
C. Y. Janda, D. Waghray, A. M. Levin, C. Thomas, and K. C. Garcia (2012)
Science 337, 59-64
   Abstract »    Full Text »    PDF »
The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling.
J. Bao, J. J. Zheng, and D. Wu (2012)
Science Signaling 5, pe22
   Abstract »    Full Text »    PDF »
Wnt/{beta}-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4.
K. C. Davidson, A. M. Adams, J. M. Goodson, C. E. McDonald, J. C. Potter, J. D. Berndt, T. L. Biechele, R. J. Taylor, and R. T. Moon (2012)
PNAS 109, 4485-4490
   Abstract »    Full Text »    PDF »
Modulation of Wnt/{beta}-catenin signaling pathway by bioactive food components.
R. S. Tarapore, I. A. Siddiqui, and H. Mukhtar (2012)
Carcinogenesis 33, 483-491
   Abstract »    Full Text »    PDF »
Regulation of developmental intercellular signalling by intracellular trafficking.
B.-Z. Shilo and E. D. Schejter (2011)
EMBO J. 30, 3516-3526
   Abstract »    Full Text »    PDF »
Novel Regulatory Mechanism of Canonical Wnt Signaling by Dopamine D2 Receptor through Direct Interaction with {beta}-Catenin.
C. Min, D.-I. Cho, K.-J. Kwon, K.-S. Kim, C. Y. Shin, and K.-M. Kim (2011)
Mol. Pharmacol. 80, 68-78
   Abstract »    Full Text »    PDF »
Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling.
L. S. Jacob, X. Wu, M. E. Dodge, C.-W. Fan, O. Kulak, B. Chen, W. Tang, B. Wang, J. F. Amatruda, and L. Lum (2011)
Science Signaling 4, ra4
   Abstract »    Full Text »    PDF »
Specific targeting of Wnt/{beta}-catenin signaling in human melanoma cells by a dietary triterpene lupeol.
R. S. Tarapore, I. A. Siddiqui, M. Saleem, V. M. Adhami, V. S. Spiegelman, and H. Mukhtar (2010)
Carcinogenesis 31, 1844-1853
   Abstract »    Full Text »    PDF »
PR55{alpha}, a Regulatory Subunit of PP2A, Specifically Regulates PP2A-mediated {beta}-Catenin Dephosphorylation.
W. Zhang, J. Yang, Y. Liu, X. Chen, T. Yu, J. Jia, and C. Liu (2009)
J. Biol. Chem. 284, 22649-22656
   Abstract »    Full Text »    PDF »
Wnt/{beta}-catenin signaling controls development of the blood-brain barrier.
S. Liebner, M. Corada, T. Bangsow, J. Babbage, A. Taddei, C. J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. (2008)
J. Cell Biol. 183, 409-417
   Abstract »    Full Text »    PDF »
Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1.
J. He, T. Sheng, A. A. Stelter, C. Li, X. Zhang, M. Sinha, B. A. Luxon, and J. Xie (2006)
J. Biol. Chem. 281, 35598-35602
   Abstract »    Full Text »    PDF »
Wnt/{beta}-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.
K. K. Mak, M.-H. Chen, T. F. Day, P.-T. Chuang, and Y. Yang (2006)
Development 133, 3695-3707
   Abstract »    Full Text »    PDF »
The Multiple Languages of Endothelial Cell-to-Cell Communication.
S. Liebner, U. Cavallaro, and E. Dejana (2006)
Arterioscler Thromb Vasc Biol 26, 1431-1438
   Abstract »    Full Text »    PDF »
Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta.
M. J. Smalley, N. Signoret, D. Robertson, A. Tilley, A. Hann, K. Ewan, Y. Ding, H. Paterson, and T. C. Dale (2005)
J. Cell Sci. 118, 5279-5289
   Abstract »    Full Text »    PDF »
{beta}-Catenin, Cancer, and G Proteins: Not Just for Frizzleds Anymore.
C. C. Malbon (2005)
Sci. STKE 2005, pe35
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882