Sci. STKE, 15 February 2005
IMMUNOLOGY Earliest Influences
The two main lineages of T cells to emerge from the thymus are distinguished by the T cell receptors that they carry, either αβ or , which confer distinctive functional properties on each cell type. Within the thymus, the development of the two lineages has been thought to occur independently. Silva-Santos et al. (see the Perspective by Rothenberg) now show that the features peculiar to T cells are not generated autonomously but are conferred directly on the cells by their immature αβ thymic counterparts. This process required signaling via a pathway already known to be essential for lymphoid organogenesis and generating effective immune responses. Thus, the developmental interaction between two lineages of T cells imparts fundamental features on one of the cell types.
Citation: Earliest Influences. Sci. STKE 2005, tw68 (2005).
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