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Sci. STKE, 1 March 2005
Vol. 2005, Issue 273, p. tr8
[DOI: 10.1126/stke.2732005tr8]


Protein Phosphatases

Stephen R. Salton*

Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA

Abstract: This Teaching Resource provides lecture notes and slides for a class covering the structure and function of protein phosphatases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the importance of phosphatases in physiology, recognized by the award of a Nobel Prize in 1992, and then proceeds to describe the two types of protein phosphatases: serine/threonine and tyrosine phosphatases. The information covered includes the structure, regulation, and substrate specificity of protein phosphatases, with an emphasis on their importance in disease and clinical settings.

*Contact information. E-mail: stephen.salton{at}; Web site,

Citation: S. R. Salton, Protein Phosphatases. Sci. STKE 2005, tr8 (2005).

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