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Sci. STKE, 8 March 2005
Vol. 2005, Issue 274, p. tr9
[DOI: 10.1126/stke.2742005tr9]


Protein Domains that Interact with Receptor Tyrosine Kinases: Structural Aspects

Ming-Ming Zhou*

Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract: This Teaching Resource provides lecture notes and slides for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.

*Contact information. E-mail: ming-ming.zhou{at}; Web site:

Citation: M.-M. Zhou, Protein Domains that Interact with Receptor Tyrosine Kinases: Structural Aspects. Sci. STKE 2005, tr9 (2005).

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