Sci. STKE, 22 March 2005
DEVELOPMENT The Right Stuff for Wing Formation
Animal organs and appendages are composed of cells with different morphologies. For example, the Drosophila wing primordium displays cells that are squamous, cuboidal, or columnar. What are their molecular determinants for this cell variation? Gibson and Perrimon examine this question by screening flies with defects in epithelial cell morphogenesis in the wing. Mutation of a signaling receptor produced a wing defect in which cells are extruded from the epithelial surface. Contrary to earlier work that implicated this signaling pathway in cell survival, it appears that the signaling pathway is instead involved in epithelial organization and that any subsequent cell death is a secondary effect. Similar conclusions are reached by Shen and Dahmann.
Citation: The Right Stuff for Wing Formation. Sci. STKE 2005, tw109 (2005).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882