Sci. STKE, 29 March 2005
REGULATORY NETWORKS Modeling Gene Regulation
Modeling gene regulation is a fundamental goal in systems biology (see the Perspective by Isaacs et al.). Rosenfeld et al. combine modeling with experiments in their analysis of gene networks. The quantitative function relating transcription factor concentration and gene factor production is termed the gene regulation function (GRF). Biochemical parameters, noise, and cellular states affect the GRF. Noise in gene expression results from fluctuations in factors such as mRNA and protein abundance and environmental conditions. Pedraza and van Oudenaarden now model and test networks in which gene interactions are controlled and quantified in single cells. Quantitation of noise propagation will assist in understanding the complex dynamics of gene networks in prokaryotic and eukaryotic systems and will assist in designing synthetic networks.
Citation: Modeling Gene Regulation. Sci. STKE 2005, tw121 (2005).
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