Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 5 April 2005
Vol. 2005, Issue 278, p. tw129
[DOI: 10.1126/stke.2782005tw129]

EDITORS' CHOICE

NEUROSCIENCE Listen, Learn, Freeze

Rats and mice learn to freeze when they hear a tone previously encountered at the same time as an electric shock. This type of learning takes place in the amygdala. Rumpel et al. examined the cellular basis of the learning by tagging the glutamate receptors that are recruited into synapses during learning with a subunit that can be detected electrophysiologically. They found that fear conditioning drives these receptors into synapses in about 35% of the cells in the lateral amygdala. Inhibition of this recruitment inhibits the formation of the tone-shock memory. If only 10 to 20% of the synapses are inactivated, learning is blocked. Thus, synaptic modification is required for behavioral learning, which is unexpectedly sensitive to the loss of a small fraction of modified synapses.

S. Rumpel, J. LeDoux, A. Zador, R. Malinow, Postsynaptic receptor trafficking underlying a form of associative learning. Science 308, 83-88 (2005). [Abstract] [Full Text]

Citation: Listen, Learn, Freeze. Sci. STKE 2005, tw129 (2005).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882