Sci. STKE, 12 April 2005
IMMUNOLOGY A New View of an Old Receptor
T cells represent a distinct lineage of T cells that undertake a range of specific immune functions. However, compared with their αβ T cell counterparts, the mode of antigen recognition by these T cells is still relatively poorly understood (see the Perspective by Garboczi). By resolving a 3.4 angstrom structure of the complex between a specific mouse T cell receptor (TCR) and its nonclassical class I major histocompatibility complex ligand, Adams et al. have generated a new model of T cell recognition, which has features of both innate immune receptor recognition and adaptive recognition through recombination of germline segments. Shin et al. arrive at similar conclusions from a survey of TCR usage at the single-cell level, which leads them to suggest that T cells focus on a relatively narrow range of antigenic ligands.
Citation: A New View of an Old Receptor. Sci. STKE 2005, tw137 (2005).
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