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Sci. STKE, 12 April 2005
Vol. 2005, Issue 279, p. tw137
[DOI: 10.1126/stke.2792005tw137]


IMMUNOLOGY A New View of an Old Receptor

{gamma}{delta} T cells represent a distinct lineage of T cells that undertake a range of specific immune functions. However, compared with their αβ T cell counterparts, the mode of antigen recognition by these T cells is still relatively poorly understood (see the Perspective by Garboczi). By resolving a 3.4 angstrom structure of the complex between a specific mouse {gamma}{delta} T cell receptor (TCR) and its nonclassical class I major histocompatibility complex ligand, Adams et al. have generated a new model of {gamma}{delta} T cell recognition, which has features of both innate immune receptor recognition and adaptive recognition through recombination of germline segments. Shin et al. arrive at similar conclusions from a survey of TCR usage at the single-cell level, which leads them to suggest that {gamma}{delta} T cells focus on a relatively narrow range of antigenic ligands.

D. N. Garboczi, "D" is not for diversity. Science 308, 209-210 (2005). [Summary] [Full Text]

E. J. Adams, Y.-H. Chien, K. C. Garcia, Structure of a {gamma}{delta} T cell receptor in complex with the nonclassical MHC T22. Science 308, 227-231 (2005). [Abstract] [Full Text]

S. Shin, R. El-Diwany, S. Schaffert, E. J. Adams, K. C. Garcia, P. Pereira, Y.-H. Chien, Antigen recognition determinants of {gamma}{delta} T cell receptors. Science 308, 252-255 (2005). [Abstract] [Full Text]

Citation: A New View of an Old Receptor. Sci. STKE 2005, tw137 (2005).

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