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Sci. STKE, 19 April 2005
Vol. 2005, Issue 280, p. pe17
[DOI: 10.1126/stke.2802005pe17]

PERSPECTIVES

How and Why Are Channels in Transporters?

Robert J. Vandenberg* and Renae M. Ryan{dagger}

Department of Pharmacology, Institute for Biomedical Research, University of Sydney, Sydney, NSW, 2006 Australia.
{dagger}Present address: Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Summary: Traditionally, transporters and ion channels have been thought of as structurally and functionally distinct proteins. However, neurotransmitter transporters can be both. Vandenberg and Ryan discuss recent developments in understanding how and why these transporters contain ion channels.

*To whom correspondence should be addressed. E-mail: robv{at}med.usyd.edu.au

Citation: R. J. Vandenberg, R. M. Ryan, How and Why Are Channels in Transporters? Sci. STKE 2005, pe17 (2005).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)