Sci. STKE, 26 April 2005
PLANT BIOLOGY Elucidating a Plant Defense Mechanism
Arabidopsis strains carrying the gene encoding RPS2 are resistant to infection by the bacterium Pseudomonas syringae, which introduces the protease effector AvrRpt2 into plant cells during pathogenesis. Coaker et al. (see the Perspective by Schulze-Lefert and Bieri) now show that the plant's own cyclophilin activates the proteolytic activity of the bacterial effector, AvrRpt2. AvrRpt2 then destroys the intermediate target protein (RIN4) in the plant, activating the plant's defensive response. It is possible that such folding of bacterial effector proteases by eukaryotic protein factors may be a common mechanism during pathogenesis.
Citation: Elucidating a Plant Defense Mechanism. Sci. STKE 2005, tw159 (2005).
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