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Sci. STKE, 3 May 2005
Vol. 2005, Issue 282, p. pe19
[DOI: 10.1126/stke.2822005pe19]

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Membrane Resealing: Synaptotagmin VII Keeps Running the Show

Norma W. Andrews*

Section of Microbial Pathogenesis and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract: Ca2+ influx, an immediate consequence of plasma membrane disruption, triggers a resealing mechanism involving exocytosis. Although this has been known for about a decade, a better understanding of the organelles involved and of the molecular machinery controlling membrane repair has been slower to emerge. Recent studies have changed this picture, by identifying lysosomes as exocytotic vesicles involved in membrane resealing and the Ca2+-binding protein synaptotagmin VII as a regulator of this process. New evidence reinforces the role of the C2A and C2B domains of synaptotagmin VII in plasma membrane repair, highlighting the importance of this molecule as a powerful tool for future studies.

*Contact information. Telephone, 203-737-2410; fax, 203-737-2630; e-mail, norma.andrews{at}yale.edu

Citation: N. W. Andrews, Membrane Resealing: Synaptotagmin VII Keeps Running the Show. Sci. STKE 2005, pe19 (2005).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Arabidopsis Synaptotagmin 1 Is Required for the Maintenance of Plasma Membrane Integrity and Cell Viability.
A. L. Schapire, B. Voigt, J. Jasik, A. Rosado, R. Lopez-Cobollo, D. Menzel, J. Salinas, S. Mancuso, V. Valpuesta, F. Baluska, et al. (2008)
PLANT CELL 20, 3374-3388
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Shaky Ground for Lysosome-Dependent Membrane Repair.
R. A. Steinhardt (2005)
Sci. STKE 2005, lc1
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