Sci. STKE, 24 May 2005
MICROBIOLOGY Membrane Engineering
The intracellular pathogen Salmonella enterica resides in a vacuole from which it translocates effector proteins into the host cell. These bacterial effectors manipulate eukaryotic functions. SifA is a key Salmonella effector protein, and sifA– mutants are highly attenuated in virulence in mice. Boucrot et al. now describe how Salmonella uses secreted effectors to negatively regulate the binding of the microtubule-associated kinesin motor onto the bacterial vacuole. SifA targets a host protein, SKIP, that down-regulates the recruitment of kinesin. In this manner, Salmonella controls the kinesin activity associated with its vacuole membrane and in turn the dynamics of membrane exchange.
Citation: Membrane Engineering. Sci. STKE 2005, tw200 (2005).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882