Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 24 May 2005
Vol. 2005, Issue 285, p. tw201
[DOI: 10.1126/stke.2852005tw201]


RNA INTERFERENCE Interfering with RNA Interference

RNA interference (RNAi) is central to a number of natural RNA-based silencing processes and is becoming a common tool used in a wide range of studies in eukaryotes. It is also being explored for its therapeutic potential. Kim et al. carried out a genome-wide screen in Caenorhabditis elegans for components of the RNAi pathway using RNAi. Although apparently a "circular" methodology, the screen identified 90 viable and lethal genes involved in RNAi, most of which were not previously linked with the process. Classes of factors include RNA binding and processing factors, chromatin-associated factors, and nuclear import and export factors. The screen also provides insight into the degree of overlap between different RNAi-based silencing pathways.

J. K. Kim, H. W. Gabel, R. S. Kamath, M. Tewari, A. Pasquinelli, J.-F. Rual, S. Kennedy, M. Dybbs, N. Bertin, J. M. Kaplan, M. Vidal, G. Ruvkun, Functional genomic analysis of RNA interference in C. elegans. Science 308, 1164-1167 (2005). [Abstract] [Full Text]

Citation: Interfering with RNA Interference. Sci. STKE 2005, tw201 (2005).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882