Sci. STKE, 7 June 2005
RECEPTORS Cytokine-Cytokine Receptor Structure
Interleukin-2 (IL-2) is central to the immune response. It forms a complex with three cell surface receptors, IL-2Rα, IL-2Rβ, and IL-2R, to form a complex that signals through activation of downstream tyrosine kinases, JAK3 and STAT. Rickert et al. have determined a 2.8 angstrom crystal structure of a complex between IL-2 and IL-2Rα. The IL-2Rα structure lacks a classical cytokine receptor fold, and the docking mode with IL-2 is distinct from known cytokine recognition modes. The structure provides a framework for the engineering of improved IL-2 therapeutics.
Citation: Cytokine-Cytokine Receptor Structure. Sci. STKE 2005, tw217 (2005).
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