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Sci. STKE, 14 June 2005
Vol. 2005, Issue 288, p. pe29
[DOI: 10.1126/stke.2882005pe29]


Human Papillomaviruses and Cell Signaling

Dennis J. McCance*

Department of Microbiology and Immunology and the James P. Wilmot Cancer Center, University of Rochester, Rochester, NY 14610, USA.

Abstract: Human papillomaviruses cause cancer of the stratified epithelium, and the incidence of infection with these viruses in the genital tract is high. The alterations in the biology of normal epithelial cells that lead to malignancy are a consequence of the activity of certain viral proteins, whose function is to create an environment conducive to the replication of the viral genome through inhibition of epithelial cell differentiation and stimulation of proliferation.

*Contact information. E-mail: Dennis_McCance{at}

Citation: D. J. McCance, Human Papillomaviruses and Cell Signaling. Sci. STKE 2005, pe29 (2005).

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Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion.
A. Pickard, A.-C. Cichon, A. Barry, D. Kieran, D. Patel, P. Hamilton, M. Salto-Tellez, J. James, and D. J. McCance (2012)
EMBO J. 31, 3092-3103
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