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Sci. STKE, 5 July 2005
Vol. 2005, Issue 291, p. pe34
[DOI: 10.1126/stke.2912005pe34]

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That Which Does Not Kill You Makes You Stronger: A Molecular Mechanism for Preconditioning

Jonathan E. McDunn and J. Perren Cobb*

Cellular Injury and Adaptation Laboratory, Departments of Surgery and Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract: Preconditioning by sublethal stress can protect a cell from subsequent injury and apoptosis through a mechanism that has been unclear. Many such stresses stimulate the formation of stress granules: transient cytoplasmic foci that contain heat shock protein as well as translationally stalled mRNA and various mRNA-binding proteins. Recent research suggests that sequestration in stress granules of TRAF2, an adaptor protein that is required for tumor necrosis factor receptor 1 signaling, may underlie preconditioning by sublethal stresses.

*Corresponding author. Cellular Injury and Adaptation Laboratory, Washington University School of Medicine, Campus Box 8109, CSRB 3366, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Telephone, 314-747-0057; fax, 314-362-7474; e-mail, cobb{at}wustl.edu

Citation: J. E. McDunn, J. P. Cobb, That Which Does Not Kill You Makes You Stronger: A Molecular Mechanism for Preconditioning. Sci. STKE 2005, pe34 (2005).

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