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Sci. STKE, 19 July 2005
Vol. 2005, Issue 293, p. cm8
[DOI: 10.1126/stke.2932005cm8]


Interleukin-13 (IL-13) Pathway

Ann Kelly-Welch1, Erica M. Hanson2, and Achsah D. Keegan1*

1 Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.
2 Department of Biology, University of Maryland Baltimore County, Catonsville, MD, USA.


Abstract: Interleukin-13 (IL-13), like IL-4, is a cytokine produced by TH2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.

*Corresponding author. E-mail, akeegan{at}

Citation: A. Kelly-Welch, E. M. Hanson, A. D. Keegan, Interleukin-13 (IL-13) Pathway. Sci. STKE 2005, cm8 (2005).

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Regulation of inflammation by interleukin-4: a review of "alternatives".
I. G. Luzina, A. D. Keegan, N. M. Heller, G. A. W. Rook, T. Shea-Donohue, and S. P. Atamas (2012)
J. Leukoc. Biol. 92, 753-764
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