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Sci. STKE, 19 July 2005
Vol. 2005, Issue 293, p. cm9
[DOI: 10.1126/stke.2932005cm9]


Interleukin-4 (IL-4) Pathway

Ann Kelly-Welch1, Erica M. Hanson2, and Achsah D. Keegan1*

1 Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.
2 Department of Biology, University of Maryland Baltimore County, Catonsville, MD, USA.


Abstract: Interleukin-4 (IL-4) is a cytokine produced by TH2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

*Corresponding author. E-mail, akeegan{at}

Citation: A. Kelly-Welch, E. M. Hanson, A. D. Keegan, Interleukin-4 (IL-4) Pathway. Sci. STKE 2005, cm9 (2005).

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