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Sci. STKE, 9 August 2005
Vol. 2005, Issue 296, p. tw292
[DOI: 10.1126/stke.2962005tw292]


PLANT BIOLOGY Avoiding Too Much of a Good Thing

Certain plants carry resistance (R) genes variants that match a particular pathogen's virulence factor. However, too much or too little of the R protein can send the plant's immune response haywire. Holt et al. now provide a genetic analysis of some of the factors that keep the immune response in Arabidopsis primed for a rapid deployment but not running rampant. One component, RAR1, somehow promotes the accumulation of the R proteins, and another, SGT1, interacts with RAR1, antagonizing its activity. SGT1 does double duty in infected plants by regulating the cell death response that limits the damage done by some pathogens.

B. F. Holt III, Y. Belkhadir, J. L. Dangl, Antagonistic control of disease resistance protein stability in the plant immune system. Science 309, 929-932 (2005). [Abstract] [Full Text]

Citation: Avoiding Too Much of a Good Thing. Sci. STKE 2005, tw292 (2005).

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