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Sci. STKE, 6 September 2005
Vol. 2005, Issue 300, p. tr25
[DOI: 10.1126/stke.3002005tr25]

TEACHING RESOURCES

A Model for Local Regulation of Translation Near Active Synapses

Kenneth S. Kosik1* and Anna M. Krichevsky2

1 Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106-5060, USA.
2Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract: Synaptic plasticity results in enduring changes in synaptic function. Localized protein synthesis is part of this process. This animation shows how a dynamic macromolecular structure, the RNA granule, may allow localized translation of proteins at the site of active synapses and thereby serve as a key element contributing to changes in protein production leading to synaptic plasticity. This animation would be useful in teaching a neurobiology or neuroscience course, where it could be used to illustrate mechanisms for activity-dependent protein translation, or in a biochemistry course or a molecular or cellular biology course, where it could be used to illustrate mechanisms governing regulation of protein translation.

*Corresponding author. E-mail, kosik{at}lifesci.ucsb.edu

Citation: K. S. Kosik, A. M. Krichevsky, A Model for Local Regulation of Translation Near Active Synapses. Sci. STKE 2005, tr25 (2005).



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