Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 20 September 2005
Vol. 2005, Issue 302, p. tw339
[DOI: 10.1126/stke.3022005tw339]

EDITORS' CHOICE

AGING Klotho for Eternal Youth?

A defect in Klotho gene expression in mice leads to a syndrome resembling aging. Kurosu et al. (see the news story by Couzin) now find that Klotho overexpression extends life span in mice. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and suppresses insulin and insulin-like growth factor-1 (IGF-1) signaling in an evolutionarily conserved mechanism for extending life span in worms, flies, and mice. Furthermore, perturbing insulin/IGF-1 signaling slows aging in Klotho-deficient mice. Thus, it appears that Klotho protein may function as an anti-aging hormone.

H. Kurosu, M. Yamamoto, J. D. Clark, J. V. Pastor, A. Nandi, P. Gurnani, O. P. McGuinness, H. Chikuda, M. Yamaguchi, H. Kawaguchi, I. Shimomura, Y. Takayama, J. Herz, C. R. Kahn, K. P. Rosenblatt, M. Kuro-o, Suppression of aging in mice by the hormone Klotho. Science 309, 1829-1833 (2005). [Abstract] [Full Text]

Citation: Klotho for Eternal Youth? Sci. STKE 2005, tw339 (2005).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882