Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 4 October 2005
Vol. 2005, Issue 304, p. tw351
[DOI: 10.1126/stke.3042005tw351]


NEUROBIOLOGY Retinoic Acid Responder

Retinoic acid causes changes in gene expression that are essential for development of spinal motor neurons in the chick. Rao and Sockanathan now find that glycerophosphate phosphodiesterase 2 (GDE2) shows increased expression in response to retinoic acid. In developing embryos, GDE2 was necessary and sufficient to promote differentiation of motor neurons.

M. Rao and S. Sockanathan, Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science 309, 2212-2215 (2005). [Abstract] [Full Text]

Citation: Retinoic Acid Responder. Sci. STKE 2005, tw351 (2005).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882