Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 18 October 2005
Vol. 2005, Issue 306, p. tw373
[DOI: 10.1126/stke.3062005tw373]


NEUROBIOLOGY Central Expression of Peripheral Cannabinoid Receptors

The discovery of endocannabinoids, which act as retrograde messengers in the brain, changed the way we think about the flow of information across the synapse. Are the endogenous actions of endocannabinoids in the brain solely accounted for by activation of CB1 receptors? Although there are hints for the presence of another receptor type, there have been no reports of an alternative CB receptor in the brain. Using reverse transcription polymerase chain reaction (RT-PCR), pharmacological, and behavioral evidence, Van Sickle et al. show that functional cannabinoid CB2 receptors, a receptor subtype traditionally considered to be expressed in immune tissues and circulating immune cells, are also present in brainstem neurons. This finding could lead to new therapies without the usual drawbacks of addiction and mind alteration traditionally associated with the consumption of cannabis derivatives.

M. D. Van Sickle, M. Duncan, P. J. Kingsley, A. Mouihate, P. Urbani, K. Mackie, N. Stella, A. Makriyannis, D. Piomelli, J. S. Davison, L. J. Marnett, V. D. Marzo, Q. J. Pittman, K. D. Patel, K. A. Sharkey, Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310, 329-332 (2005). [Abstract] [Full Text]

Citation: Central Expression of Peripheral Cannabinoid Receptors. Sci. STKE 2005, tw373 (2005).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882