Sci. STKE, 25 October 2005
MODELING A Model of Regulation
It is becoming possible to recognize basic principles of regulatory circuits that control biological processes. Brandman et al. (see the Perspective by Bornholdt) compared three distinct biological regulatory systems and note that all contain multiple positive feedback loops with fast and slow time courses. They used mathematical models of the systems to show that these characteristics allow the systems to be relatively insensitive to fluctuations in signal input and allow for the kinetics of activation and inactivation to be adjusted independently to best fit the physiological requirements of the system.
Citation: A Model of Regulation. Sci. STKE 2005, tw378 (2005).
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