Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 15 November 2005
Vol. 2005, Issue 310, p. tw408
[DOI: 10.1126/stke.3102005tw408]

EDITORS' CHOICE

PHYSIOLOGY Dueling Hunger Hormones?

Ghrelin, a circulating peptide hormone produced in the stomach, has attracted much attention because of its stimulatory effect on food intake, but the effect of ghrelin may represent only half the story. Using a bioinformatics approach, Zhang et al. (see the Perspective by Nogueiras and Tschöp) show that ghrelin encodes a second peptide hormone that is processed from the same protein precursor as ghrelin. In rodents, a synthetic version of this hormone, obestatin, has the opposite physiological effect as ghrelin--it suppresses food intake. Obestatin mediates its actions through an orphan G protein-coupled receptor, GPR39, which shares sequences with, but is distinct from, the receptor targeted by ghrelin.

J. V. Zhang, P.-G. Ren, O. Avsian-Kretchmer, C.-W. Luo, R. Rauch, C. Klein, A. J. W. Hsueh, Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310, 996-999 (2005). [Abstract] [Full Text]

R. Nogueiras and M. Tschöp, Separation of conjoined hormones yields appetite rivals. Science 310, 985-986 (2005). [Summary] [Full Text]

Citation: Dueling Hunger Hormones? Sci. STKE 2005, tw408 (2005).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882