Sci. STKE, 22 November 2005
IMMUNOLOGY Reshaping the Synapse
The immune synapse forms at the interface between a T cell and an antigen-presenting cell (APC) and is composed of discrete domains of stimulatory molecules and receptors critical for T cell activation. Mossman et al. have imposed physical constraints on the synapse domains using a hybrid junction between a live cell and an anchored lipid bilayer (representing the APC surface). The authors directly tested the effects of membrane reorganization on the signals delivered by the synapse. Constraint of T cell receptor ligand pairs to the periphery--rather than the center of the synapse, where they normally coalesce--sustained rather than diminished synapse signaling, establishing a relation between the duration of T cell receptor signals and their position in the synapse.
Citation: Reshaping the Synapse. Sci. STKE 2005, tw414 (2005).
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