Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 22 November 2005
Vol. 2005, Issue 311, p. tw414
[DOI: 10.1126/stke.3112005tw414]

EDITORS' CHOICE

IMMUNOLOGY Reshaping the Synapse

The immune synapse forms at the interface between a T cell and an antigen-presenting cell (APC) and is composed of discrete domains of stimulatory molecules and receptors critical for T cell activation. Mossman et al. have imposed physical constraints on the synapse domains using a hybrid junction between a live cell and an anchored lipid bilayer (representing the APC surface). The authors directly tested the effects of membrane reorganization on the signals delivered by the synapse. Constraint of T cell receptor ligand pairs to the periphery--rather than the center of the synapse, where they normally coalesce--sustained rather than diminished synapse signaling, establishing a relation between the duration of T cell receptor signals and their position in the synapse.

K. D. Mossman, G. Campi, J. T. Groves, M. L. Dustin, Altered TCR signaling from geometrically repatterned immunological synapses. Science 310, 1191-1193 (2005). [Abstract] [Full Text]

Citation: Reshaping the Synapse. Sci. STKE 2005, tw414 (2005).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882