Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 29 November 2005
Vol. 2005, Issue 312, p. tw423
[DOI: 10.1126/stke.3122005tw423]

EDITORS' CHOICE

RECEPTORS Signaling from Wingless

Despite the extensive study of the Wingless (Wg) or Wnt signaling pathway in regulating development and cancer, a previously unrecognized mechanism has been uncovered for Wg signaling at developing synapses in the Drosophila nervous system. Mathew et al. (see the Perspective by Arias) found that the Wg receptor DFrizzled2 can be cleaved and translocated from the plasma membrane to the area of the cell just outside the nucleus. In response to Wg signals, the C-terminal portion of the receptor then enters the nucleus, where it might act to regulate gene expression. Expression of an Fz2 mutant that could not be cleaved failed to rescue synapse formation in flies that expressed a mutant of Fz2 with defective signaling.

D. Mathew, B. Ataman, J. Chen, Y. Zhang, S. Cumberledge, V. Budnik, Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310, 1344-1347 (2005). [Abstract] [Full Text]

A. M. Arias, Frizzled at the cutting edge of the synapse. Science 310, 1284-1285 (2005). [Summary] [Full Text]

Citation: Signaling from Wingless. Sci. STKE 2005, tw423 (2005).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882