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Sci. STKE, 3 January 2006
Vol. 2006, Issue 316, p. eg1
[DOI: 10.1126/stke.3162006eg1]

EDITORIAL GUIDES

2005: Signaling Breakthroughs of the Year

Elizabeth M. Adler1*, Nancy R. Gough2, and L. Bryan Ray3

1 Associate Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
2 Managing Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
3 Editor of Science's STKE and Senior Editor of Science, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Summary: 2005 was particularly notable for the range and scope of exciting advances in cell signaling research. Nominations from leading scientists ranged from plant signaling, neurobiology, and immunology to systems biology and structural biology. In plant biology, a new piece added to a long-standing puzzle in auxin signaling was discovered. The exploitation and regulation of RNA in cell signaling was also in the limelight. Intriguing new twists were highlighted in relation to functional and dysfunctional signaling in the brain, calcium-mediated signals, and the innate immune response. Finally, mathematical and statistical analysis of biochemical networks provided new insights into the circuitry of cell signaling pathways.

*Corresponding author. E-mail, eadler{at}aaas.org

Citation: E. M. Adler, N. R. Gough, L. B. Ray, 2005: Signaling Breakthroughs of the Year. Sci. STKE 2006, eg1 (2006).

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