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Sci. STKE, 17 January 2006
Vol. 2006, Issue 318, p. pe3
[DOI: 10.1126/stke.3182006pe3]


Phosphatidylserine and Signal Transduction: Who Needs Whom?

M. Carmen Martínez, Corinne Kunzelmann, and Jean-Marie Freyssinet*

Unité 143 INSERM and Institut d’Hématologie et d’Immunologie, Faculté de Médecine, Université Louis Pasteur, 67085 Strasbourg, France.

Abstract: The plasma membrane, long considered a simple barrier between the extracellular and intracellular compartments, is now thought to play a pivotal role in many physiological processes that regulate the communication of cells with their environment. On one hand, the plasma membrane directly participates in intracellular signaling; on the other hand, changes in membrane structure contribute to the transcellular transfer of biological information. Among the membrane constituents, phosphatidylserine is a major actor implicated in these effects. Evidence now exists for a role for phosphatidylserine redistribution in modulating the activities of several membrane proteins during signaling in nonapoptotic T lymphocytes.

*Corresponding author. E-mail: jean-marie.freyssinet{at}

Citation: M. C. Martínez, C. Kunzelmann, J.-M. Freyssinet, Phosphatidylserine and Signal Transduction: Who Needs Whom? Sci. STKE 2006, pe3 (2006).

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