Sci. STKE, 17 January 2006
NEUROSCIENCE An Exciting Inhibitory Neuron
Discovered 30 years ago, axo-axonic or Chandelier cells are the most specific inhibitory neurotransmitter -aminobutyric acid-releasing (GABAergic) cell type known and are regularly used in textbooks to illustrate the strategic placement of inhibition on the axon. Szabadics et al. show that instead of inhibiting postsynaptic cells, axo-axonic cells can actually excite postsynaptic cells, which leads to an unprecedented phenomenon in the cortex: a single GABAergic cell that can reliably activate the cortical network.
Citation: An Exciting Inhibitory Neuron. Sci. STKE 2006, tw484 (2006).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882